You are here

  • Home
  • Online First
  • Impact of drug-coated balloon for vascular luminal dilatational remodeling after balloon angioplasty in intracranial atherosclerotic stenosis – a retrospective cohort study

Article Text

Article menu
Download PDFPDF
Ischemic stroke
Original research
Impact of drug-coated balloon for vascular luminal dilatational remodeling after balloon angioplasty in intracranial atherosclerotic stenosis – a retrospective cohort study
  1. Qianhao Ding1,
  2. Yingkun He1,
  3. Jingge Zhao2,
  4. Wenbo Liu1,
  5. Zhengpeng Zhu3,
  6. Yukuan Pang1,
  7. Yang Zhao4,
  8. Yang Liu1,
  9. Zi-liang Wang1,
  10. Liangfu Zhu1,
  11. Yanyan He1,
  12. Tianxiao Li1,5
  1. 1Department of Cerebrovascular Disease, Zhengzhou University People's Hospital, Henan Provincial People's Hospital; Henan Provincial Cerebrovascular Interventional Innovation Engineering Technology Research Center, Henan International Joint Laboratory of Cerebrovascular Disease, Zhengzhou, Henan, China
  2. 2Department of Scientific Research and Foreign Affairs, Henan Provincial People's Hospital, Zhengzhou, Henan, China
  3. 3Department of Cerebrovascular Disease, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China
  4. 4School of Medical Engineering, Xinxiang Medical University, Xinxiang, Henan, China
  5. 5Sanya Hospital of Traditional Chinese Medicine, Sanya, Hainan, China
  1. Correspondence to Dr Tianxiao Li; dr.litianxiao{at}zzu.edu.cn; Dr Yanyan He; hyyz2017{at}163.com

Abstract

Objective This study aimed to examine the effect of drug-coated balloons (DCBs) on vascular luminal dilatational remodeling (VLDR) following simple balloon angioplasty.

Methods A retrospective cohort study was conducted using data from patients diagnosed with intracranial atherosclerotic stenosis (ICAS), who were treated exclusively with balloon angioplasty at Henan Provincial People’s Hospital between June 2019 and April 2023. Inverse probability weighting (IPW) was used to create balanced cohorts of patients who underwent drug-coated balloon angioplasty (DCBA) and plain old balloon angioplasty (POBA). The primary endpoint was VLDR occurrence during follow-up, with the effect of DCBA on VLDR assessed by adjusted multivariate regression.

Results The study included 110 patients who underwent simple percutaneous transluminal angioplasty, with 60 in the DCBA group and 50 in the POBA group. At follow-up, the stenosis rate in the DCBA group was lower than in the POBA group (P<0.001). The decrease in stenosis rate (DSR) was greater in the DCBA group compared with the POBA group (P<0.001). Nineteen patients (31.7%) in the DCBA group experienced VLDR, whereas only four (8%) in the POBA group developed VLDR, a statistically significant difference (P=0.002). After IPW adjustment, differences in stenosis rate (34.17 (20.00, 46.72) vs 46.00 (37.88, 70.00), P<0.001), DSR (-1.66 (-16.71, 11.40) vs -18.00 (-28.00, -3.00), P<0.001) and VLDR incidence (32.2% vs 9.9%, P<0.001) between the DCBA and POBA groups remained significant. Multivariate regression analysis identified DCBA as an independent factor influencing VLDR occurrence.

Conclusion This study demonstrated that, compared with POBA, DCBA increases VLDR occurrence in ICAS patients during follow-up.

  • Angioplasty
  • Stenosis
  • Stroke
  • Balloon

Data availability statement

Data are available upon reasonable request. Data are available from the corresponding author upon reasonable request.

https://doi.org/10.1136/jnis-2024-022281

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Data availability statement

    Data are available upon reasonable request. Data are available from the corresponding author upon reasonable request.

    View Full Text

    Footnotes

    • QD and YiH are joint first authors.

    • QD and YiH contributed equally.

    • YaH and TL contributed equally.

    • Contributors QD drafted and revised the manuscript, conceived and designed the study, and acquired the data. YiH provided study ideas and resources, and acquired the data. JZ directed statistics and article picture drawing, and revised the manuscript. WL acquired data and revised the manuscript. ZZ, YP, YL acquired data, applied software and statistics. YZ acquired, monitored and validated data. Z-lW, LZ formulated the overarching research goals and aims and supervised the whole study. YaH designed the study, wrote the statistical analysis plan, and drafted and revised the manuscript. TL provided financial and administrative support. YiH is responsible for the overall content as guarantor.

    • Funding This work was supported by Henan Medical Science and Technology Research Plan Provincial and Ministerial Youth Project (SBGJ202303001), Henan Province Key Research and Development & Promotion Special (Science and Technology) Foundation (222102310378 and 232102231042), National Health Commission Capacity Building and Continuing Education Project (GWJJ2023100101) and Key Research and Development Project of Henan Province (241111313200).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.