Baseline patient characteristics
| Characteristics | ATLAS subjects who met comparator trial inclusion/exclusion criteria | Comparator trial | |
| Crude | MAIC weighted | ||
| LVIS | |||
| No of patients | 241 | 184 | 153 |
| Age (years) (mean (SD)) | 59.0 (10.3) | 58.2 (10.9) | 58.3 (10.5) |
| Aneurysm location (n (%)) | |||
| Internal carotid artery | 67 (27.8) | 52 (28.1) | 43 (28.1) |
| Anterior cerebral artery | 49 (20.3) | 69 (37.3) | 57 (37.3) |
| Middle cerebral artery | 29 (12.0) | 20 (11.1) | 17 (11.1) |
| Posterior cerebral artery | 2 (0.8) | 7 (3.9) | 6 (3.9) |
| Basilar artery | 81 (33.6) | 32 (17.6) | 27 (17.6) |
| Superior cerebellar artery | 3 (1.2) | 1 (0.7) | 1 (0.7) |
| Vertebral artery | 10 (4.2) | 2 (1.3) | 2 (1.3) |
| Index aneurysm prior rupture (n (%)) | 28 (11.6) | 27 (14.4) | 22 (14.4) |
| Neck width (mm) (mean (SD)) | 4.5 (1.4) | 4.2 (1.4) | 4.2 (1.4) |
| Dome height (mm) (mean (SD)) | 5.9 (2.3) | 5.9 (2.4) | 6.0 (2.2) |
| Dome width (mm) (mean (SD)) | 5.8 (2.2) | 5.6 (2.0) | 5.5 (2.3) |
| Index aneurysm dome-to-neck ratio (mean (SD)) | 1.2 (0.3) | 1.3 (0.4) | 1.3 (0.4) |
| WEB-IT | |||
| No of patients | 141 | 109 | 150 |
| Age (mean (SD)) | 59.7 (10.4) | 59 (10.3) | 59.0 (10.2) |
| Aneurysm location (n (%)) | |||
| Anterior communicating artery | 47 (33.3) | 29/109 (26.7) | 40 (26.7) |
| Basilar apex | 67 (47.5) | 43/109 (39.3) | 59 (39.3) |
| Internal carotid artery bifurcation/terminus | 6 (4.3) | 4/109 (4.0) | 6 (4.0) |
| Middle cerebral artery bifurcation | 21 (14.9) | 33/109 (30.0) | 45 (30.0) |
| Index aneurysm prior rupture (n (%)) | 17 (12.1) | 7/109 (6.0) | 9 (6.0) |
| Index aneurysm size (mm) (mean (SD)) | 6.0 (1.6) | 6.4 (1.6) | 6.4 (1.6) |
| Index aneurysm dome-to-neck ratio (mean (SD)) | 1.2 (0.3) | 1.3 (0.3) | 1.3 (0.2) |
ATLAS, Safety and Effectiveness of the Treatment of Wide Neck, Saccular Intracranial Aneurysms With the Neuroform Atlas Stent System; LVIS, Pivotal Study of the Low Profile Visualized Intraluminal Support; MAIC, matching adjusted indirect comparison method; WEB-IT, Woven EndoBridge Intrasaccular Therapy Study.