Baseline, imaging, and treatment characteristics compared between mTICI 2b and mTICI 3 patients before and after propensity score matching
| Before propensity score matching | After propensity score matching | |||||||
| Patients, number (%) | Patients, number (%) | |||||||
| All (n=290) | mTICI 2b (n=132) | mTICI 3 (n=158) | P value* | All (n=226) | mTICI 2b (n=113) | mTICI 3 (n=113) | P value* | |
| Baseline characteristics | ||||||||
| Age (years), median (IQR) | 74 (62–81) | 74 (61–81) | 74 (63–82) | 0.50† | 74 (62–81) | 73 (60–81) | 74 (63–81) | 0.69† |
| Male sex | 145/290 (50.0%) | 64/132 (48.5%) | 81/158 (51.3%) | 0.64‡ | 117/226 (51.8%) | 57/113 (50.4%) | 60/113 (53.1%) | 0.69‡ |
| Medical history | ||||||||
| Atrial fibrillation | 132/290 (45.5%) | 54/132 (40.9%) | 78/158 (49.4%) | 0.15‡ | 100/226 (44.2%) | 45/113 (39.8%) | 55/113 (48.7%) | 0.18‡ |
| Arterial hypertension | 208/289 (72.0%) | 90/131 (68.7%) | 118/158 (74.7%) | 0.26‡ | 163/225 (72.4%) | 76/112 (67.9%) | 87/113 (77.0%) | 0.13‡ |
| Diabetes | 58/290 (20.0%) | 21/132 (15.9%) | 37/158 (23.4%) | 0.11‡ | 42/226 (18.6%) | 17/113 (15.0%) | 25/113 (22.1%) | 0.17‡ |
| Dyslipidemia | 106/288 (36.8%) | 47/130 (36.2%) | 59/158 (37.3%) | 0.84‡ | 89/224 (39.7%) | 42/111 (37.8%) | 47/113 (41.6%) | 0.57‡ |
| Prestroke mRS score | 0.23‡ | 0.88‡ | ||||||
| 0 | 208/290 (71.7%) | 89/132 (67.4%) | 119/158 (75.3%) | 164/226 (72.6%) | 82/113 (72.6%) | 82/113 (72.6%) | ||
| 1 | 42/290 (14.5%) | 24/132 (18.2%) | 18/158 (11.4%) | 28/226 (12.4%) | 13/113 (11.5%) | 15/113 (13.3%) | ||
| 2 | 40/290 (13.8%) | 19/132 (14.4%) | 21/158 (13.3%) | 34/226 (15.0%) | 18/113 (15.9%) | 16/113 (14.2%) | ||
| Admission NIHSS score, median (IQR)§ | 17 (13–19) | 17 (14–19) | 16 (12–19) | 0.23† | 17 (13–19) | 17 (14–19) | 17 (12–20) | 0.77† |
| Imaging characteristics | ||||||||
| Occlusion site | 0.58‡ | 0.71‡ | ||||||
| ICA | 89/290 (30.7%) | 42/132 (31.8%) | 47/158 (29.7%) | 78/226 (34.5%) | 38/113 (33.6%) | 40/113 (35.4%) | ||
| MCA – M1 | 171/290 (59.0%) | 79/132 (59.8%) | 92/158 (58.2%) | 127/226 (56.2%) | 66/113 (58.4%) | 61/113 (54.0%) | ||
| MCA – M2 | 30/290 (10.3%) | 11/132 (8.3%) | 19/158 (12.0%) | 21/226 (9.3%) | 9/113 (8.0%) | 12/113 (10.6%) | ||
| Baseline ASPECTS, median (IQR) | 5 (4–5) | 5 (4–5) | 5 (4–5) | 0.88† | 5 (4–5) | 5 (4–5) | 5 (4–5) | 0.99† |
| Workflow times | ||||||||
| Last known well/symptom, onset to admission (min), median (IQR) | 225 (108–613) | 230 (98–662) | 217 (112–598) | 0.90† | 237 (104–644) | 243 (93–684) | 226 (118–603) | >0.99† |
| Missing data, number. | 34 | 14 | 20 | 24 | 11 | 13 | ||
| Groin to flow restoration (min), median (IQR) | 35 (24–51) | 35 (25–51) | 35 (23–51) | 0.42† | 35 (24–50) | 37 (26–51) | 32 (23–48) | 0.13† |
| Missing data, number | 10 | 6 | 4 | 10 | 6 | 4 | ||
| Treatment characteristics | ||||||||
| Administration of IVT | 105/290 (36.2%) | 47/132 (35.6%) | 58/158 (36.7%) | 0.85‡ | 76/226 (33.6%) | 37/113 (32.7%) | 39/113 (34.5%) | 0.78‡ |
| General anesthesia | 224/288 (77.8%) | 100/131 (76.3%) | 124/157 (79.0%) | 0.59‡ | 172/224 (76.1%) | 84/112 (74.3%) | 88/112 (77.9%) | 0.53‡ |
| Recanalization attempts during EVT, median (IQR) | 2 (1–3) | 2 (1–3) | 1 (1–3) | 0.005† | 2 (1–3) | 2 (1–3) | 1 (1–2) | <0.001† |
*Characteristics were compared between mTICI 2b and mTICI patients.
†Mann-Whitney U test for continuous variables
‡χ2 test for categorical variables.
ASPECTS, Alberta Stroke Program Early CT Score; EVT, endovascular therapy; ICA, internal carotid artery; IVT, intravenous thrombolysis; MCA, middle cerebral artery; mRS, modified Rankin Scale; mTICI, modified Thrombolysis In Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale.